pain in the balls
When something that was already annoying your ass has now moved up to your balls because it's decided to be even more of a pain.
My job is a pain in the balls now. I can't even take a leak without my boss bugging me.
My mom finally got fed up with my sister and now she’s a pain in the balls.
That kid next door started chasing my dog, so now he's a pain in the balls.