I guess that's it
The worst way to end a conversation, like you just said 'I hate you' to everyone you've ever met and you're still not done being rude.
'I guess that's it' after a whole argument about who had the better dog.
'I guess that's it' when she said that to him and he knew she was still mad about the whole dog thing.
'I guess that's it' as he walked away, completely ignoring her.