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A stand up bitch is a woman who doesn't back down when a man talks trash and takes it up the ass. She's your best friend but also your worst enemy when you mess up.
"You said I was a stand up bitch? I'm gonna beat you to death with your own face."
"He calls me a stand up bitch, but I'm the one who beats him up when he lies to me."
"She's a stand up bitch, and I'm the only one who knows she's got a gun in her purse."