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A pain in the ayn is like having your butt cheek slapped by a flaming hot meatball. It’s not just annoying, it’s a full-blown disaster inside your ass.
My math teacher is a pain in the ayn. He makes me do 100 problems every day.
This traffic jam is a pain in the ayn. I’ve been stuck for three hours.
My little brother is a pain in the ayn. He won’t stop screaming.