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G’s up means the gangsters are on top and the bitches are getting stepped on. It’s like the ultimate flex when you walk in and say it.
Yo, G’s up, Ho’s down! I just robbed the bank, you’re paying for my weed.
G’s up, Ho’s down! I just broke up with my ex, and she’s outta my life.
G’s up, Ho’s down! I just got my diploma, and I’m gonna be rich.