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Down to fuck is when you talk about girls with your guy friends like you're the only one who knows they exist and they're just a bunch of clueless meatheads.
Bro, I'm down to fuck this girl tomorrow. You're still trying to figure out how to ask your ex back.
D2F, man. I'm getting ready to hit that like it's a buffet.
Down to fuck? I'm down to fuck, but I'm also down to beat up anyone who tries to steal my girl.