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A Muhammad is a random Muslim guy with no name. People use it like a swear word when they're tired of hearing about Muslims. It's like saying 'Joe Schmoe' but for Muslims and it's kinda rude.
Yo, that Muhammad in class is the worst, man!
I don't know why they call him Muhammad. It's just a random name!
Man, that Muhammad is so annoying, I want to punch him.