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When you trick a girl into passing out so you can do what you want with her. Also, a drink that has roofies and qualudes to knock someone out like a sack of bricks.
I a cosby'd my math teacher with a Jell-o shot and a roofie. She passed out during the test.
He slipped a roofie into my soda at the mall. I woke up in his car.
My friend a cosby'd her crush by adding a pill to his smoothie. He woke up in a hotel bed with a stranger.